Isharpal Singh, MS Programming T Cells to kill Tumor Cells Surgery, chemotherapy, and radiation therapy have been considered as the cornerstones of cancer therapy for years. But with the advent of targeted therapies like Imatinib (GleevecÂź) and Trastuzumab (HerceptinÂź) there has been a considerable shift in the standard treatments for…
By Dr. Vaishali Kulkarni Telomeres are specific DNA-protein structures found at both ends of each chromosomes. They prevents the chromosome ends from sticking together and protecting chromosomes from degradation(1). The telomere regions are made up of repetitive nucleotide sequences. In vertebrates, the telomere sequence is TTAGGG and this…
By IsharPal Singh, MS The past 20 years have brought an unprecedented increase in the accumulation of knowledge about cancer cells. The study of genomics has yielded a tremendous amount of data regarding the signaling cascades involved in cancerous cells. Yet, the increase in no. of deaths from cancer remind…
By Suchitra Chari, MS The human microbiome comprises of all the microorganisms and their genes present in the human body. This totals to around a trillion in number found in site specific places like the skin, mouth, nasal cavities, gut and uterus. When we use the term âmicrobeâ in the…
By Perry McLimore, MD., JD. Gamekeeperâs thumb was described in 1955 due to chronic laxity found in the joint in Scottish gamekeepers.1 The gamekeepers would break the necks of small game by placing the neck of the animal between the ground and their thumbs. Skierâs thumb is…
By Suchitra Chari, MS The fatigue caused by functional changes (mainly neurochemical changes) in the Central Nervous System (CNS) due to prolonged exercise is known as Central Fatigue. The main neurotransmitters that are known to be affected are serotonin or 5-HT (levels increase) and dopamine (levels decrease). Serotonin and…
By Perry McLimore, MD., JD. ELBOW The elbow is a synovial joint, which means the joint has a synovial capsule and is bathed in synovial fluid for cartilage nourishment. The bones that make up the elbow joint are the humerus, which is the upper arm bone. Below or distal to…
By Joanne P. Shelby-Klein BSN RN The shingles vaccine, sometimes referred to as the âshingles shotâ is often seen advertised in pharmacies and Doctorsâ offices, leading patients to wonder if they should get the vaccine and what is it for. Shingles is the laymanâs term for the Herpes…
By Joanne P. Shelby-Klein BSN RN Chronic Fatigue Syndrome (CFS) is also known as Myalgic Encephalomyelitis (ME) and affects 836,000 to 2.5 Million Americans (Institute of Medicine report) or about 2.8% of adults. These numbers may actually be higher because between 84-91% of the cases…